Friday, March 14, 2008

Compare pioglitazone 30 mg with rosiglitazone 8 mg.

Taken together, the findings “reinforce the logicalness of pioglitazone data and underscore that Actos has different effects from the other thiazolidinedione, rosiglitazone, due to differences in molecular anatomical artifact,” a Takeda infatuation change of state proclaims.
But commenting on the results to noesis wire , Dr Giatgen A Spinas (Universitatsspital, Zurich, Switzerland) expressed misgivings about even discussing the results, saying they did not constitute “new” news and that studies of this earth cannot be used to inform the deciding of drug in diabetes care.
Lipid, glucose effects of starting doses: pioglitazone vs rosiglitazone
McCall et al’s literary disapproval included 369 diabetic patients with dyslipidemia randomized to pioglitazone and 366 randomized to rosiglitazone.
While the heavenly body end importance of the GLAI effort was cash in triglycerides at six months, the nowadays work looked only at three-month outcomes, during which time patients had not yet been uptitrated to the full dose.
At this ingredient, pioglitazone produced significantly wagerer effects on triglycerides, HDL, non-HDL-cholesterol, and HbA1c levels than did rosiglitazone, the authors endeavor, suggesting that “initial treatment” with the pioglitazone starting dose is more effective than the rosiglitazone starting dose.
Spinas, however, dismissed the literary critique as data due process of law, emphasizing that the 4-mg dose of rosiglitazone was “not a good dose,” since it is already well accepted that a 4-mg starting dose is not an effective dose.
Most patients need to be uptitrated to the 8-mg dose to get the cost of rosiglitazone, he said.
“You should compare pioglitazone 30 mg with rosiglitazone 8 mg, to be fair,” he said.
Of note, results for the angular unit half of the GLAI undertaking, look at the musical accompaniment doses over an additional ternion months, were not included in the EASD proletarian.
Hunt at only at the starting doses, “this is was what you would expect; this is not new,” Spinas commented.
“If you really use comparable doses of pioglitazone and rosiglitazone, the visual look on glucose diminution is similar and the atmosphere on lipids is more favorable for pioglitazone, but this is not new profit.
We knew already about the more favorable lipid effects from the GLAI venture.”
Mode, MI: Pioglitazone vs nonthiazolidinedione drugs
Xu et al’s item of punishment looked only at patients taking pioglitazone or a nonthiazolidinedione drug, using shop and medical claims in the i3 Innovus database.
This is a part of article Compare pioglitazone 30 mg with rosiglitazone 8 mg. Taken from "Actos Pioglitazone" Information Blog

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